The article discusses the challenges faced by scientists Mann and Hotez in combating rising anti-science sentiment and conspiracy theories, particularly regarding vaccination and COVID-19. Their book, Science Under Siege, not only criticizes these anti-scientific movements but also advocates for constructive dialogue and civic engagement as potential solutions. Unfortunately, the situation in the U.S. has deteriorated further since the book’s publication, portraying a troubling landscape for science, heavily influenced by far-right ideologies. Examples include attacks on scientists like Hotez, who has been targeted by anti-vaccine advocates despite their unfounded claims linking vaccines to autism. The article underscores a growing disconnect between science and policy under current leadership, suggesting that the future of American science may hinge on voter action. It closes with a reminder of Marie Curie’s belief in the power of understanding to mitigate fear.